Venous thromboembolism in adults with sickle cell disease: a serious and under-recognized complication

RP Naik, MB Streiff, C Haywood Jr, JA Nelson… - The American journal of …, 2013 - Elsevier
BACKGROUND: Sickle cell disease is recognized as a hypercoagulable state; however, the
frequency and characteristics of venous thromboembolism in sickle cell patients have not
been well defined. The purpose of this study was to establish the prevalence and risk factors
for venous thromboembolism in a large cohort of patients with sickle cell disease and
determine the relationship between venous thromboembolism and mortality. METHODS: We
performed a cross-sectional study of 404 sickle cell disease patients cared for at the Sickle …