The metabolism of hemoglobin and bile pigment in hemolytic disease

WH Crosby - The American journal of medicine, 1955 - Elsevier
1. The production of hemoglobin in normal humans is about 90 mg. per kg. of body weight
per day, and an equal amount of hemoglobin is destroyed each day. The life span of
hemoglobin is the same as that of red cells, about 120 days. The bile pigments derived from
the hemoglobin of worn-out red cells and other sources amounts to about 250 mg. per day in
a 70 kg. man. The mechanisms of formation and degradation of hemoglobin and the fate of
bile pigments are discussed. 2. 2. In hemolytic anemia the production and destruction of …