Small molecule targeting miR-34a for cancer therapy
Z Xiao, Y Chen - Molecular & Cellular Oncology, 2015 - Taylor & Francis
Z Xiao, Y Chen
Molecular & Cellular Oncology, 2015•Taylor & FrancismiR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer
Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone
selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a
was silenced. Restoration of miR-34a by Rubone represents a promising therapeutic
approach against cancer.
Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone
selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a
was silenced. Restoration of miR-34a by Rubone represents a promising therapeutic
approach against cancer.
miR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a was silenced. Restoration of miR-34a by Rubone represents a promising therapeutic approach against cancer.
Taylor & Francis Online