Region-specific regulation of inflammation and pathogenesis in experimental autoimmune encephalomyelitis
AS Archambault, J Sim, EE McCandless… - Journal of …, 2006 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis
and is characterized by an infiltrate of predominately T cells and macrophages in the spinal
cord and brain. In both the spinal cord and the cerebellum, Th1 cells direct inflammation to
antigen-rich white matter tracts, and there is a TNFR1-dependent recruitment of CD11bhi
cells in both regions. In the spinal cord, parenchymal invasion, demyelination and clinical
symptoms are associated with TNFR1-dependant parenchymal induction (especially …
and is characterized by an infiltrate of predominately T cells and macrophages in the spinal
cord and brain. In both the spinal cord and the cerebellum, Th1 cells direct inflammation to
antigen-rich white matter tracts, and there is a TNFR1-dependent recruitment of CD11bhi
cells in both regions. In the spinal cord, parenchymal invasion, demyelination and clinical
symptoms are associated with TNFR1-dependant parenchymal induction (especially …