TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation
MAT Gimenez, JE Sim, JH Russell - Journal of neuroimmunology, 2004 - Elsevier
VCAM-1 is an adhesion molecule that is important to leukocyte movement across the blood–
brain barrier and is involved in the formation of destructive CNS inflammatory lesions in
experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). We
examined VCAM-1 expression in the CNS of animals with passively induced EAE and found
abundant expression not only on the CNS endothelium but also on astrocytes. We show that
tumor necrosis factor receptor-1 (TNFR1) signaling is required for VCAM-1 expression by …
brain barrier and is involved in the formation of destructive CNS inflammatory lesions in
experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). We
examined VCAM-1 expression in the CNS of animals with passively induced EAE and found
abundant expression not only on the CNS endothelium but also on astrocytes. We show that
tumor necrosis factor receptor-1 (TNFR1) signaling is required for VCAM-1 expression by …