Abnormal hepatic energy homeostasis in type 2 diabetes

J Szendroedi, M Chmelik, AI Schmid, P Nowotny… - Hepatology, 2009 - journals.lww.com
Increased hepatocellular lipids relate to insulin resistance and are typical for individuals with
type 2 diabetes mellitus (T2DM). Steatosis and T2DM have been further associated with
impaired muscular adenosine triphosphate (ATP) turnover indicating reduced mitochondrial
fitness. Thus, we tested the hypothesis that hepatic energy metabolism could be impaired
even in metabolically well-controlled T2DM. We measured hepatic lipid volume fraction
(HLVF) and absolute concentrations of γATP, inorganic phosphate (Pi), phosphomonoesters …