Lipoxins, Aspirin-Triggered Epi-Lipoxins, Lipoxin Stable Analogues, and the Resolution of Inflammation: Stimulation of Macrophage Phagocytosis of Apoptotic …

S Mitchell, G Thomas, K Harvey, D Cottell… - Journal of the …, 2002 - journals.lww.com
Lipoxins (LX) are eicosanoids with antiinflammatory activity in glomerulonephritis (GN) and
inflammatory diseases, hypersensitivity, and ischemia reperfusion injury. It has been
demonstrated that LXA 4 stimulates non-phlogistic phagocytosis of apoptotic
polymorphonuclear neutrophils (PMN) by monocyte-derived macrophages (Mφ) in vitro,
suggesting a role for LX as endogenous pro-resolution lipid mediators. It is here reported
that LXA 4, LXB 4, the aspirin-triggered LX (ATL) epimer, 15-epi-LXB 4, and a stable …