A microRNA cluster as a target of genomic amplification in malignant lymphoma

H Tagawa, M Seto - Leukemia, 2005 - nature.com
H Tagawa, M Seto
Leukemia, 2005nature.com
A microRNA cluster as a target of genomic amplification in malignant lymphoma value of
sequential classical karyotyping during disease progression. 8 An abnormal karyotype
developed in eight of our patients, usually preceding, and in every case associated with,
leukemic evolution as observed in seven of 19 patients developing AML and one patient
developing RAEB with monosomy 7. In summary, screening of 33 cases of MDS with normal
karyotype failed to detect a monoallelic deletion of PI-PLCβ1 gene. All FAB classes and …
A microRNA cluster as a target of genomic amplification in malignant lymphoma value of sequential classical karyotyping during disease progression. 8 An abnormal karyotype developed in eight of our patients, usually preceding, and in every case associated with, leukemic evolution as observed in seven of 19 patients developing AML and one patient developing RAEB with monosomy 7.
In summary, screening of 33 cases of MDS with normal karyotype failed to detect a monoallelic deletion of PI-PLCβ1 gene. All FAB classes and IPSS risk groups were represented. This seems to indicate that the cryptic deletion that appears to be associated with very short survival is a rare event in MDS and thus of limited utility as a prognostic marker. This letter is also a call to other groups to share their experience with the use of this marker.
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