[HTML][HTML] Minimal GVHD following in-vitro Tcell–depleted allogeneic stem cell transplantation with reduced-intensity conditioning allowing subsequent infusions of …
RMY Barge, S Osanto, WAFE Marijt… - Experimental …, 2003 - Elsevier
OBJECTIVE: Allogeneic stem cell transplantation (alloSCT) following reduced-intensity
conditioning offers a relatively nontoxic regimen while preserving rapid and sustained
engraftment. Acute and chronic graft-vs-host disease (GVHD) is, however, a significant
cause of severe morbidity. To reduce the incidence of GVHD, we treated a group of high-risk
patients with a reduced-intensity conditioning regimen followed by in vitro T-cell–depleted
alloSCT using Campath 1-H incubation. PATIENTS AND METHODS: Eighteen patients were …
conditioning offers a relatively nontoxic regimen while preserving rapid and sustained
engraftment. Acute and chronic graft-vs-host disease (GVHD) is, however, a significant
cause of severe morbidity. To reduce the incidence of GVHD, we treated a group of high-risk
patients with a reduced-intensity conditioning regimen followed by in vitro T-cell–depleted
alloSCT using Campath 1-H incubation. PATIENTS AND METHODS: Eighteen patients were …