A systemic gentamicin pathway across the stria vascularis
CF Dai, PS Steyger - Hearing research, 2008 - Elsevier
The mechanism (s) by which systemically-administered aminoglycosides enter the cochlea
remain poorly understood. To elucidate which mechanisms may be involved, we co-
administered different molar ratios of gentamicin and fluorescent gentamicin (GTTR) to mice
in three different regimens:(1) gentamicin (150, 300 or 600mg/kg) containing a constant 300:
1 molar ratio of gentamicin: GTTR;(2) 300mg/kg gentamicin containing a variable molar ratio
of gentamicin: GTTR (150: 1–600: 1), or (3) an increasing dose of gentamicin (150 …
remain poorly understood. To elucidate which mechanisms may be involved, we co-
administered different molar ratios of gentamicin and fluorescent gentamicin (GTTR) to mice
in three different regimens:(1) gentamicin (150, 300 or 600mg/kg) containing a constant 300:
1 molar ratio of gentamicin: GTTR;(2) 300mg/kg gentamicin containing a variable molar ratio
of gentamicin: GTTR (150: 1–600: 1), or (3) an increasing dose of gentamicin (150 …