Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease

A Videnovic, C Noble, KJ Reid, J Peng… - JAMA …, 2014 - jamanetwork.com
Importance Diurnal fluctuations of motor and nonmotor symptoms and a high prevalence of
sleep-wake disturbances in Parkinson disease (PD) suggest a role of the circadian system
in the modulation of these symptoms. However, surprisingly little is known regarding
circadian function in PD and whether circadian dysfunction is involved in the development of
sleep-wake disturbances in PD. Objective To determine the relationship between the timing
and amplitude of the 24-hour melatonin rhythm, a marker of endogenous circadian …