[HTML][HTML] Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic …
N Tibrewal, Y Wu, V D'mello, R Akakura… - Journal of biological …, 2008 - ASBMB
Efficient clearance of apoptotic cells is essential for tissue homeostasis, allowing for cellular
turnover without inflammatory consequences. The Mer (Nyk and c-Eyk) receptor tyrosine
kinase (Mertk) is involved in two aspects of apoptotic cell clearance by acting as a receptor
for Gas6, a γ-carboxylated phosphatidylserine-binding protein that bridges apoptotic and
viable cells. First, Mertk acts in a bona fide engulfment pathway in concert with αvβ5 integrin
by regulating cytoskeletal assemblages, and second, it acts as a negative regulator for …
turnover without inflammatory consequences. The Mer (Nyk and c-Eyk) receptor tyrosine
kinase (Mertk) is involved in two aspects of apoptotic cell clearance by acting as a receptor
for Gas6, a γ-carboxylated phosphatidylserine-binding protein that bridges apoptotic and
viable cells. First, Mertk acts in a bona fide engulfment pathway in concert with αvβ5 integrin
by regulating cytoskeletal assemblages, and second, it acts as a negative regulator for …