[HTML][HTML] EEA1, an Early Endosome-Associated Protein.: EEA1 IS A CONSERVED α-HELICAL PERIPHERAL MEMBRANE PROTEIN FLANKED BY CYSTEINE “ …
FT Mu, JM Callaghan, O Steele-Mortimer… - Journal of Biological …, 1995 - ASBMB
Early endosomes are cellular compartments receiving endocytosed material and sorting
them for vesicular transport to late endosomes and lysosomes or for recycling to the plasma
membrane. We have cloned a human cDNA encoding an evolutionarily conserved 180-kDa
protein on early endosomes named EEA1 (Early Endosome Antigen1). EEA1 is associated
with early endosomes since it co-localizes by immunofluorescence with the transferrin
receptor and with Rab5 but not with Rab7. Immunoelectron microscopy shows that it is …
them for vesicular transport to late endosomes and lysosomes or for recycling to the plasma
membrane. We have cloned a human cDNA encoding an evolutionarily conserved 180-kDa
protein on early endosomes named EEA1 (Early Endosome Antigen1). EEA1 is associated
with early endosomes since it co-localizes by immunofluorescence with the transferrin
receptor and with Rab5 but not with Rab7. Immunoelectron microscopy shows that it is …