Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism

VM Olkkonen, S Li - Progress in lipid research, 2013 - Elsevier
Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute a family of
sterol and phosphoinositide binding proteins conserved in eukaryotes. The mechanisms of
ORP function have remained incompletely understood. However, several ORPs are present
at membrane contact sites and control the activity of enzymatic effectors or assembly of
protein complexes, with impacts on signaling, vesicle transport, and lipid metabolism. An
increasing number of protein interaction partners of ORPs have been identified, providing …