Obesity and pregnancy are associated with a combination of insulin resistance and
inflammatory changes which exacerbate in combination. Based on the similarity between
the inflammatory transcriptomes of adipose tissue and placenta, we hypothesized that the
placenta develops exaggerated inflammation in response to obesity. The aim of this study
was to characterize placental inflammatory mediators and macrophage accumulation in
relation to peripheral inflammation in obesity. Placental macrophages and maternal …