[HTML][HTML] Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4
Inflammation in adipose tissue plays an important role in the pathogenesis of obesity-
associated complications. However, the detailed cellular events underlying the inflammatory
changes at the onset of obesity have not been characterized. Here we show that an acute
HFD challenge is unexpectedly associated with elevated alternative (M2) macrophage
polarization in adipose tissue mediated by Natural Killer T (NKT) cells. Upon 4d HFD
feeding, NKT cells are activated, promote M2 macrophage polarization and induce arginase …
associated complications. However, the detailed cellular events underlying the inflammatory
changes at the onset of obesity have not been characterized. Here we show that an acute
HFD challenge is unexpectedly associated with elevated alternative (M2) macrophage
polarization in adipose tissue mediated by Natural Killer T (NKT) cells. Upon 4d HFD
feeding, NKT cells are activated, promote M2 macrophage polarization and induce arginase …