[HTML][HTML] A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse
A Moles, L Murphy, CL Wilson, JB Chakraborty… - Journal of …, 2014 - Elsevier
Background & Aims Neutrophils are important immune effectors required for sterile and non-
sterile inflammatory responses. However, neutrophils are associated with pathology in drug-
induced liver injury, acute alcoholic liver disease, and ischemia-reperfusion injury. An
understanding of the complex mechanisms that control neutrophil recruitment to the injured
liver is desirable for developing strategies aimed at limiting neutrophil-mediated cellular
damage. Methods Wt, tlr2−/−, tlr4−/−, and s100a9−/− mice were administered CCl 4 either …
sterile inflammatory responses. However, neutrophils are associated with pathology in drug-
induced liver injury, acute alcoholic liver disease, and ischemia-reperfusion injury. An
understanding of the complex mechanisms that control neutrophil recruitment to the injured
liver is desirable for developing strategies aimed at limiting neutrophil-mediated cellular
damage. Methods Wt, tlr2−/−, tlr4−/−, and s100a9−/− mice were administered CCl 4 either …