M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease
J Wan, M Benkdane, F Teixeira-Clerc, S Bonnafous… - Hepatology, 2014 - journals.lww.com
Alcoholic and nonalcoholic fatty liver disease (ALD and NAFLD) are the predominant
causes of liver-related mortality in Western countries. We have shown that limiting classical
(M1) Kupffer cell (KC) polarization reduces alcohol-induced liver injury. Herein, we
investigated whether favoring alternatively activated M2 KCs may protect against ALD and
NAFLD. Ongoing alcohol drinkers and morbidly obese patients, with minimal hepatic injury
and steatosis, displayed higher hepatic expression of M2 genes, as compared to patients …
causes of liver-related mortality in Western countries. We have shown that limiting classical
(M1) Kupffer cell (KC) polarization reduces alcohol-induced liver injury. Herein, we
investigated whether favoring alternatively activated M2 KCs may protect against ALD and
NAFLD. Ongoing alcohol drinkers and morbidly obese patients, with minimal hepatic injury
and steatosis, displayed higher hepatic expression of M2 genes, as compared to patients …