Background & Aims Low-grade chronic inflammation is a cardinal feature of the metabolic
syndrome, yet its pathogenesis is not well defined. The purpose of this study was to examine
the role of TRAIL receptor (TR) signaling in the pathogenesis of obesity-associated
inflammation using mice with the genetic deletion of TR. Methods TR knockout (TR−/−) mice
and their littermate wild-type (WT) mice were fed a diet high in saturated fat, cholesterol and
fructose (FFC) or chow. Metabolic phenotyping, liver injury, and liver and adipose tissue …