[HTML][HTML] Peroxisome proliferator-activated receptors and hepatic stellate cell activation
T Miyahara, L Schrum, R Rippe, S Xiong… - Journal of Biological …, 2000 - ASBMB
The present study examined the roles of peroxisome proliferator-activated receptors (PPAR)
in activation of hepatic stellate cells (HSC), a pivotal event in liver fibrogenesis. RNase
protection assay detected mRNA for PPARγ1 but not that for the adipocyte-specific γ2
isoform in HSC isolated from sham-operated rats, whereas the transcripts for neither
isoforms were detectable in HSC from cholestatic liver fibrosis induced by bile duct ligation
(BDL). Semi-quantitative reverse transcriptase-polymerase chain reaction confirmed a 70 …
in activation of hepatic stellate cells (HSC), a pivotal event in liver fibrogenesis. RNase
protection assay detected mRNA for PPARγ1 but not that for the adipocyte-specific γ2
isoform in HSC isolated from sham-operated rats, whereas the transcripts for neither
isoforms were detectable in HSC from cholestatic liver fibrosis induced by bile duct ligation
(BDL). Semi-quantitative reverse transcriptase-polymerase chain reaction confirmed a 70 …