[PDF][PDF] THE IN VITRO PRESERVATION AND POST-TRANSFUSION SURVIVAL OF STORED BLOOD

JF Ross, CA Finch, WC Peacock… - The Journal of clinical …, 1947 - Am Soc Clin Investig
JF Ross, CA Finch, WC Peacock, ME Sammons
The Journal of clinical investigation, 1947Am Soc Clin Investig
The therapeutic value of blood transfusion is well established and experiences during World
War II demonstrated the urgent need for readily available supplies of whole blood. Blood
plasma and plasma" substitutes," although effective in combatting shock and in replacing
plasma lost into burned and traumatized areas, cannot restore erythrocytes lost from
hemorrhage or intravascular destruction (1). Civilian and military experiences have
demonstrated the practicability and value of whole blood stored or" banked" in advance of …
The therapeutic value of blood transfusion is well established and experiences during World War II demonstrated the urgent need for readily available supplies of whole blood. Blood plasma and plasma" substitutes," although effective in combatting shock and in replacing plasma lost into burned and traumatized areas, cannot restore erythrocytes lost from hemorrhage or intravascular destruction (1).
Civilian and military experiences have demonstrated the practicability and value of whole blood stored or" banked" in advance of need, and im-mediately available for use in any emergency. In civilian practice, the blood bank has greatly facilitated the procedure of blood transfusion and has made feasible the routine use of whole blood transfusion. In military practice, banked blood is an absolute essential since it is impractical to bleed donors for transfusion under combat conditions, but it is under these very conditions that whole blood is most urgently needed. Although stored blood is highly desirable prac-tically and economically, to be effective, the via-bility of the erythrocytes must be maintained dur-ing the period of storage since the major purpose of transfusing whole blood is to supply the re-cipient with functional erythrocytes. Erythrocytes destroyed immediately after transfusion not only are valueless to the recipient, but the intravascular liberation of largeamounts of hemoglobin from
The Journal of Clinical Investigation