[PDF][PDF] Networking at the level of host immunity: immune cell interactions during persistent viral infections

CT Ng, LM Snell, DG Brooks, MBA Oldstone - Cell host & microbe, 2013 - cell.com
CT Ng, LM Snell, DG Brooks, MBA Oldstone
Cell host & microbe, 2013cell.com
Persistent viral infections are the result of a series of connected events that culminate in
diminished immunity and the inability to eliminate infection. By building our understanding of
how distinct components of the immune system function both individually and collectively in
productive versus abortive responses, new potential therapeutic targets can be developed to
overcome immune dysfunction and thus fight persistent infections. Using lymphocytic
choriomeningitis virus (LCMV) as a model of a persistent virus infection and drawing …
Persistent viral infections are the result of a series of connected events that culminate in diminished immunity and the inability to eliminate infection. By building our understanding of how distinct components of the immune system function both individually and collectively in productive versus abortive responses, new potential therapeutic targets can be developed to overcome immune dysfunction and thus fight persistent infections. Using lymphocytic choriomeningitis virus (LCMV) as a model of a persistent virus infection and drawing parallels to persistent human viral infections such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV), we describe the cellular relationships and interactions that determine the outcome of initial infection and highlight immune targets for therapeutic intervention to prevent or treat persistent infections. Ultimately, these findings will further our understanding of the immunologic basis of persistent viral infection and likely lead to strategies to treat human viral infections.
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