[HTML][HTML] On the processing of proghrelin to ghrelin
X Zhu, Y Cao, K Voodg, DF Steiner - Journal of Biological Chemistry, 2006 - ASBMB
The orexigenic hormone ghrelin is a 28-amino-acid peptide derived from a 99-amino-acid
precursor and acylated at Ser-3, which was initially isolated from rat stomach. In addition to
stimulating appetite and growth, it also plays various important roles in energy homeostasis
and in the cardiovascular and immune systems. Although analysis of its physiological effects
has yielded many significant results, much less information is available on its biosynthesis
and the mechanism of its acylation. In this report, we have studied the endoproteolytic …
precursor and acylated at Ser-3, which was initially isolated from rat stomach. In addition to
stimulating appetite and growth, it also plays various important roles in energy homeostasis
and in the cardiovascular and immune systems. Although analysis of its physiological effects
has yielded many significant results, much less information is available on its biosynthesis
and the mechanism of its acylation. In this report, we have studied the endoproteolytic …