Regulation of cardiac hypertrophy by intracellular signalling pathways

J Heineke, JD Molkentin - Nature reviews Molecular cell biology, 2006 - nature.com
Nature reviews Molecular cell biology, 2006nature.com
The mammalian heart is a dynamic organ that can grow and change to accommodate
alterations in its workload. During development and in response to physiological stimuli or
pathological insults, the heart undergoes hypertrophic enlargement, which is characterized
by an increase in the size of individual cardiac myocytes. Recent findings in genetically
modified animal models implicate important intermediate signal-transduction pathways in
the coordination of heart growth following physiological and pathological stimulation.
Abstract
The mammalian heart is a dynamic organ that can grow and change to accommodate alterations in its workload. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes. Recent findings in genetically modified animal models implicate important intermediate signal-transduction pathways in the coordination of heart growth following physiological and pathological stimulation.
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