[HTML][HTML] Estrogen stimulates heat shock protein 90 binding to endothelial nitric oxide synthase in human vascular endothelial cells: effects on calcium sensitivity and …
KS Russell, MP Haynes, T Caulin-Glaser… - Journal of Biological …, 2000 - ASBMB
Estradiol (E 2) causes endothelium-dependent vasodilation, mediated, in part, by enhanced
nitric oxide (NO) release. We have previously shown that E 2-induced activation of
endothelial nitric oxide synthase (eNOS) reduces its calcium dependence. This pathway of
eNOS activation is unique to a limited number of stimuli, including shear stress, the
response to which is herbimycin-inhibitable. Consistent with this, herbimycin and
geldanamycin pretreatment of human umbilical vein endothelial cells (HUVEC) abrogated E …
nitric oxide (NO) release. We have previously shown that E 2-induced activation of
endothelial nitric oxide synthase (eNOS) reduces its calcium dependence. This pathway of
eNOS activation is unique to a limited number of stimuli, including shear stress, the
response to which is herbimycin-inhibitable. Consistent with this, herbimycin and
geldanamycin pretreatment of human umbilical vein endothelial cells (HUVEC) abrogated E …