Disruption of IP3R2-mediated Ca2+ signaling pathway in astrocytes ameliorates neuronal death and brain damage while reducing behavioral deficits after focal …
Inositol trisphosphate receptor (IP 3 R)-mediated intracellular Ca 2+ increase is the major
Ca 2+ signaling pathway in astrocytes in the central nervous system (CNS). Ca 2+ increases
in astrocytes have been found to modulate neuronal function through gliotransmitter release.
We previously demonstrated that astrocytes exhibit enhanced Ca 2+ signaling in vivo after
photothrombosis (PT)-induced ischemia, which is largely due to the activation of G-protein
coupled receptors (GPCRs). The aim of this study is to investigate the role of astrocytic IP 3 …
Ca 2+ signaling pathway in astrocytes in the central nervous system (CNS). Ca 2+ increases
in astrocytes have been found to modulate neuronal function through gliotransmitter release.
We previously demonstrated that astrocytes exhibit enhanced Ca 2+ signaling in vivo after
photothrombosis (PT)-induced ischemia, which is largely due to the activation of G-protein
coupled receptors (GPCRs). The aim of this study is to investigate the role of astrocytic IP 3 …