Methotrexate reduces incidence of vascular diseases in veterans with psoriasis or rheumatoid arthritis
S Prodanowich, F Ma, JR Taylor, C Pezon… - Journal of the American …, 2005 - Elsevier
BACKGROUND: Methotrexate (MTX) is a folate analogue used in the treatment of moderate
to severe psoriasis and rheumatoid arthritis (RA). It oppositely affects inflammation and
hyperhomocysteinemia—two independent risk factors for vascular disease. To date, there
are no published reports evaluating the impact of these potentially paradoxical action of
MTX. OBJECTIVE: The purpose of this study was to evaluate the effect of MTX therapy on
the incidence of vascular disease in patients with psoriasis and RA. METHODS: We …
to severe psoriasis and rheumatoid arthritis (RA). It oppositely affects inflammation and
hyperhomocysteinemia—two independent risk factors for vascular disease. To date, there
are no published reports evaluating the impact of these potentially paradoxical action of
MTX. OBJECTIVE: The purpose of this study was to evaluate the effect of MTX therapy on
the incidence of vascular disease in patients with psoriasis and RA. METHODS: We …