[HTML][HTML] Increased oxidative stress in obesity and its impact on metabolic syndrome

S Furukawa, T Fujita, M Shimabukuro… - The Journal of …, 2017 - Am Soc Clin Investig
S Furukawa, T Fujita, M Shimabukuro, M Iwaki, Y Yamada, Y Nakajima, O Nakayama…
The Journal of clinical investigation, 2017Am Soc Clin Investig
Obesity is a principal causative factor in the development of metabolic syndrome. Here we
report that increased oxidative stress in accumulated fat is an important pathogenic
mechanism of obesity-associated metabolic syndrome. Fat accumulation correlated with
systemic oxidative stress in humans and mice. Production of ROS increased selectively in
adipose tissue of obese mice, accompanied by augmented expression of NADPH oxidase
and decreased expression of antioxidative enzymes. In cultured adipocytes, elevated levels …
Obesity is a principal causative factor in the development of metabolic syndrome. Here we report that increased oxidative stress in accumulated fat is an important pathogenic mechanism of obesity-associated metabolic syndrome. Fat accumulation correlated with systemic oxidative stress in humans and mice. Production of ROS increased selectively in adipose tissue of obese mice, accompanied by augmented expression of NADPH oxidase and decreased expression of antioxidative enzymes. In cultured adipocytes, elevated levels of fatty acids increased oxidative stress via NADPH oxidase activation, and oxidative stress caused dysregulated production of adipocytokines (fat-derived hormones), including adiponectin, plasminogen activator inhibitor–1, IL-6, and monocyte chemotactic protein–1. Finally, in obese mice, treatment with NADPH oxidase inhibitor reduced ROS production in adipose tissue, attenuated the dysregulation of adipocytokines, and improved diabetes, hyperlipidemia, and hepatic steatosis. Collectively, our results suggest that increased oxidative stress in accumulated fat is an early instigator of metabolic syndrome and that the redox state in adipose tissue is a potentially useful therapeutic target for obesity-associated metabolic syndrome.
The Journal of Clinical Investigation