[HTML][HTML] Tumor necrosis factor (TNF)-α inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase
P Peraldi, GS Hotamisligil, WA Buurman… - Journal of Biological …, 1996 - ASBMB
Tumor necrosis factor (TNF)-α plays a central role in the state of insulin resistance
associated with obesity. It has previously been shown that one important mechanism by
which TNF-α interferes with insulin signaling is through the serine phosphorylation of insulin
receptor substrate-1 (IRS-1), which can then function as an inhibitor of the tyrosine kinase
activity of the insulin receptor (IR). However, the receptors and the signaling pathway used
by TNF-α that mediate the inhibition of IR activity are unknown. We show here that human …
associated with obesity. It has previously been shown that one important mechanism by
which TNF-α interferes with insulin signaling is through the serine phosphorylation of insulin
receptor substrate-1 (IRS-1), which can then function as an inhibitor of the tyrosine kinase
activity of the insulin receptor (IR). However, the receptors and the signaling pathway used
by TNF-α that mediate the inhibition of IR activity are unknown. We show here that human …