[HTML][HTML] Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling
R Shibata, N Ouchi, S Kihara, K Sato… - Journal of Biological …, 2004 - ASBMB
Obesity is a risk factor for the development of cardiovascular diseases that are associated
with impaired angiogenesis. Adiponectin is an adipocyte-specific adipocytokine with anti-
atherogenic and anti-diabetic properties, and its plasma levels are reduced in association
with obesity-linked diseases. Here, we investigated whether adiponectin regulates
angiogenesis in response to tissue ischemia using adiponectin knock-out (KO) mice.
Angiogenic repair of ischemic hind limbs was impaired in adiponectin-KO mice compared …
with impaired angiogenesis. Adiponectin is an adipocyte-specific adipocytokine with anti-
atherogenic and anti-diabetic properties, and its plasma levels are reduced in association
with obesity-linked diseases. Here, we investigated whether adiponectin regulates
angiogenesis in response to tissue ischemia using adiponectin knock-out (KO) mice.
Angiogenic repair of ischemic hind limbs was impaired in adiponectin-KO mice compared …