[HTML][HTML] Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages
SH Rhee, BW Jones, V Toshchakov, SN Vogel… - Journal of Biological …, 2003 - ASBMB
Engagement of Toll-like receptor (TLR) proteins activates multiple signal transduction
pathways. These studies show that engagement of TLR2 and TLR4 leads to rapid
phosphorylation of the transcription factor STAT1 at serine 727 (Ser-727 STAT1) in murine
macrophages. Only TLR4 engagement induced STAT1 phosphorylation at tyrosine 701,
although this response was delayed compared with Ser-727 STAT1 phosphorylation.
Inhibition of phosphatidylinositol 3′-kinase using LY294002 blocked TLR4-induced STAT1 …
pathways. These studies show that engagement of TLR2 and TLR4 leads to rapid
phosphorylation of the transcription factor STAT1 at serine 727 (Ser-727 STAT1) in murine
macrophages. Only TLR4 engagement induced STAT1 phosphorylation at tyrosine 701,
although this response was delayed compared with Ser-727 STAT1 phosphorylation.
Inhibition of phosphatidylinositol 3′-kinase using LY294002 blocked TLR4-induced STAT1 …