Fatty acids can activate proinflammatory pathways leading to the development of insulin
resistance, but the mechanism is undiscovered. Toll like receptor 2 (TLR2) recognizes lipids,
activates proinflammatory pathways, and is genetically associated with inflammatory
diseases. This study aimed to examine the role of TLR2 in palmitate-induced insulin
resistance in C2C12 myotubes. Treatment with palmitate rapidly induced the association of
myeloid differentiation factor 88 (MyD88) with the TLR2 receptor, activated the stress-linked …