Activation of human peripheral monocytes by angiotensin II
AWA Hahn, U Jonas, FR Bühler, TJ Resink - FEBS letters, 1994 - Elsevier
AWA Hahn, U Jonas, FR Bühler, TJ Resink
FEBS letters, 1994•ElsevierThis study has investigated the ability of the vasoconstrictor peptide angiotensin II to activate
human peripheral blood monocytes. Activation was monitored by measuring both the
release of tumor necrosis factor α from monocytes and their adhesion to monolayers of
human endothelial cells. Angiotensin II-elicited activation of monocytes was dose-
dependent (half-maxiinally effective concentration≈ 0.2 nM), saturable (maximally effective
concentration≈ 5 nM), and sensitive to inhibition by the angiotensin type 1 receptor …
human peripheral blood monocytes. Activation was monitored by measuring both the
release of tumor necrosis factor α from monocytes and their adhesion to monolayers of
human endothelial cells. Angiotensin II-elicited activation of monocytes was dose-
dependent (half-maxiinally effective concentration≈ 0.2 nM), saturable (maximally effective
concentration≈ 5 nM), and sensitive to inhibition by the angiotensin type 1 receptor …
Abstract
This study has investigated the ability of the vasoconstrictor peptide angiotensin II to activate human peripheral blood monocytes. Activation was monitored by measuring both the release of tumor necrosis factor α from monocytes and their adhesion to monolayers of human endothelial cells. Angiotensin II-elicited activation of monocytes was dose-dependent (half-maxiinally effective concentration ≈ 0.2 nM), saturable (maximally effective concentration ≈ 5 nM), and sensitive to inhibition by the angiotensin type 1 receptor antagonist ZD 7155. Such direct actions imply that angiotensin II is an important candidate stimulus for the subendothelial infiltration of monocytes observed in atherogenesis and hypertension.
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