TNF-α acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient—effects on leptin and insulin signaling pathways
Acting in the hypothalamus, tumor necrosis factor-α (TNF-α) produces a potent anorexigenic
effect. However, the molecular mechanisms involved in this phenomenon are poorly
characterized. In this study, we investigate the capacity of TNF-α to activate signal
transduction in the hypothalamus through elements of the pathways employed by the
anorexigenic hormones insulin and leptin. High dose TNF-α promotes a reduction of 25% in
12h food intake, which is an inhibitory effect that is marginally inferior to that produced by …
effect. However, the molecular mechanisms involved in this phenomenon are poorly
characterized. In this study, we investigate the capacity of TNF-α to activate signal
transduction in the hypothalamus through elements of the pathways employed by the
anorexigenic hormones insulin and leptin. High dose TNF-α promotes a reduction of 25% in
12h food intake, which is an inhibitory effect that is marginally inferior to that produced by …