Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells
R Tirumalai, TR Kumar, KH Mai, S Biswal - Toxicology letters, 2002 - Elsevier
Acrolein, an α, β-unsaturated aldehyde, is by far the strongest electrophile present in
cigarette smoke which is involved in several lung pathophysiological conditions. Acrolein
depletes glutathione and creates thiol imbalance. Acrolein due to thiol imbalance as well as
covalent modification of cysteine is known to inhibit the activity of redox sensitive
transcription factors such as NF-κB and AP-1. Exposure of human type II lung epithelial
(A549) cells to non-lethal dose of acrolein (150 fmol/cell for 1 h) depletes 80% of …
cigarette smoke which is involved in several lung pathophysiological conditions. Acrolein
depletes glutathione and creates thiol imbalance. Acrolein due to thiol imbalance as well as
covalent modification of cysteine is known to inhibit the activity of redox sensitive
transcription factors such as NF-κB and AP-1. Exposure of human type II lung epithelial
(A549) cells to non-lethal dose of acrolein (150 fmol/cell for 1 h) depletes 80% of …