[HTML][HTML] Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression
H Sasaki, H Sato, K Kuriyama-Matsumura… - Journal of Biological …, 2002 - ASBMB
In mammalian cultured cells, the cystine/glutamate exchange transport mediated by system
xc− is important to maintain intracellular GSH levels. System xc− consists of two protein
components, xCT and the heavy chain of 4F2 antigen. The activity of system xc− is induced
by various stimuli, including electrophilic agents like diethyl maleate. In the present study,
we have investigated the mechanism of the transcriptional regulation of xCT mRNA by
diethyl maleate. The xCT gene consisted of twelve exons and sequence analysis identified …
xc− is important to maintain intracellular GSH levels. System xc− consists of two protein
components, xCT and the heavy chain of 4F2 antigen. The activity of system xc− is induced
by various stimuli, including electrophilic agents like diethyl maleate. In the present study,
we have investigated the mechanism of the transcriptional regulation of xCT mRNA by
diethyl maleate. The xCT gene consisted of twelve exons and sequence analysis identified …