Abnormal blood biomarkers in early pregnancy are associated with preeclampsia: a meta-analysis

RE Allen, E Rogozinska, K Cleverly, J Aquilina… - European Journal of …, 2014 - Elsevier
Objective Our aim was to evaluate the strength of association between abnormal levels of
first trimester maternal blood biomarkers and the risk of preeclampsia. Study design We
searched MEDLINE, EMBASE and Cochrane databases from inception until April 2013.
Studies that assessed the association between any abnormal maternal blood biomarker in
the first trimester and preeclampsia were included. Two independent reviewers selected
studies, extracted data and assessed the quality. Results were summarized as pooled odds …