Longevity in spontaneously hypertensive mice

G Schlager - Experimental Gerontology, 1981 - Elsevier
Longevity was investigated in three lines of mice with genetically selected differences in
systolic blood pressure. Lifespan was shortest in the line with elevated blood pressure and
significantly longer in the normotensive and hypotensive lines. In unmated animals this
difference in lifespan between the low blood pressure line and high blood pressure line was
200–300 days. The difference in the bred mice was somewhat less but was confounded by
differences in reproductive capacity.