The prognostic impact of amplification of chromosome 1(C1A) in newly diagnosed multiple myeloma (nMM) patients treated with the most commonly used bortezomib‐based triplet regimens is unclear. In this study, we analyzed the outcome of novel triplet therapies in a series of unselected patients with C1A detected by FISH. We identified 28 unselected nMM patients with C1A who had a gain of 1q21 locus. Despite 50% of patients being diagnosed at ISS stage 1 or 2 and 93% having no other high‐risk molecular findings, the median overall survival of all patients was only 37 months, with 8 deaths (29%) occurring 8–37 months after diagnosis. Those who died had a median of four lines (range was 1–8) of therapy. Moreover, 71% of patients were non‐Caucasian. Extra‐osseous and CNS involvement occurred in 36 and 11% of patients respectively. Gain of the long arm of chromosome 1 detected by FISH remains a high‐risk prognostic marker even in the setting of novel triplet therapies.Am. J. Hematol. 89:616–620, 2014. © 2014 Wiley Periodicals, Inc.