[HTML][HTML] Peroxiredoxin 4 improves insulin biosynthesis and glucose-induced insulin secretion in insulin-secreting INS-1E cells
Oxidative folding of (pro) insulin is crucial for its assembly and biological function. This
process takes place in the endoplasmic reticulum (ER) and is accomplished by protein
disulfide isomerase and ER oxidoreductin 1β, generating stoichiometric amounts of
hydrogen peroxide (H 2 O 2) as byproduct. During insulin resistance in the prediabetic state,
increased insulin biosynthesis can overwhelm the ER antioxidative and folding capacity,
causing an imbalance in the ER redox homeostasis and oxidative stress. Peroxiredoxin 4 …
process takes place in the endoplasmic reticulum (ER) and is accomplished by protein
disulfide isomerase and ER oxidoreductin 1β, generating stoichiometric amounts of
hydrogen peroxide (H 2 O 2) as byproduct. During insulin resistance in the prediabetic state,
increased insulin biosynthesis can overwhelm the ER antioxidative and folding capacity,
causing an imbalance in the ER redox homeostasis and oxidative stress. Peroxiredoxin 4 …