Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

SB Heymsfield, AS Greenberg, K Fujioka, RM Dixon… - Jama, 1999 - jamanetwork.com
ContextThe protein hormone leptin is important to the homeostatic regulation of body weight.
Treatment with exogenous leptin may affect weight loss. ObjectiveTo determine the
relationship between increasing doses of exogenous leptin administration and weight loss
in both lean and obese adults. DesignA randomized, double-blind, placebo-controlled,
multicenter, escalating dose cohort trial conducted from April 1997 to October 1998.
SettingFour university nutrition and obesity clinics and 2 contract clinical research clinics …