Diabetes, a new mutation in the mouse

KP Hummel, MM Dickie, DL Coleman - Science, 1966 - science.org
KP Hummel, MM Dickie, DL Coleman
Science, 1966science.org
Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal
recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in
man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia,
polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans
suggest neogenesis to compensate for insulin depletion.
Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.
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