Cholecystokinin in the brains of obese and nonobese mice

E Straus, RS Yalow - Science, 1979 - science.org
E Straus, RS Yalow
Science, 1979science.org
Extracts of the cerebral cortex of genetically obese (ob/ob) mice with hyperphagia contain
0.05±0.02 microgram (mean±standard error) of cholecystokinin octapeptide equivalent per
gram of wet weight compared to 0.15±0.01 microgram per gram for their nonobese
littermates and 0.20±0.01 microgram per gram for normal LAF1 mice. These findings are
suggestive of a causal relation between the diminished brain immunoreactive
cholecystokinin content and the unrestrained appetite of the obese mice.
Extracts of the cerebral cortex of genetically obese (ob/ob) mice with hyperphagia contain 0.05 ± 0.02 microgram (mean ± standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15 ± 0.01 microgram per gram for their nonobese littermates and 0.20 ± 0.01 microgram per gram for normal LAF1 mice. These findings are suggestive of a causal relation between the diminished brain immunoreactive cholecystokinin content and the unrestrained appetite of the obese mice.
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