The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge
R He, MK Oyoshi, JYT Wang, MR Hodge, H Jin… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: Cutaneous prostaglandin (PG) D2 levels increase after scratching.
Chemoattractant receptor–homologous molecule expressed on receptor on TH2 cells
(CRTH2) mediates chemotaxis to PGD2 and is expressed on TH2 cells and eosinophils,
which infiltrate skin lesions in patients with atopic dermatitis. OBJECTIVE: We sought to
examine the role of CRTH2 in a murine model of atopic dermatitis. METHODS: CRTH2−/−
mice and wild-type control animals were epicutaneously sensitized by means of repeated …
Chemoattractant receptor–homologous molecule expressed on receptor on TH2 cells
(CRTH2) mediates chemotaxis to PGD2 and is expressed on TH2 cells and eosinophils,
which infiltrate skin lesions in patients with atopic dermatitis. OBJECTIVE: We sought to
examine the role of CRTH2 in a murine model of atopic dermatitis. METHODS: CRTH2−/−
mice and wild-type control animals were epicutaneously sensitized by means of repeated …