Human mast cells drive memory CD4+ T cells toward an inflammatory IL-22+ phenotype

N Gaudenzio, C Laurent, S Valitutti… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Mast cells are key components of the skin microenvironment in psoriasis,
yet their functional role in this T-cell–mediated inflammatory disorder remains to be
elucidated. OBJECTIVE: To define the impact of T-cell/mast-cell cognate interactions on the
cytokines produced by TH cells. METHODS: We used human primary mast cells and
effector/memory CD4+ T cells for in vitro coculture experiments, and we analyzed TH cells
responses by using cytometry. CD4+ T-cell/mast-cell conjugates in skin lesions from patients …