New insights into the role of T cells in atopic dermatitis and allergic contact dermatitis

A Trautmann, M Akdis, EB Bröcker, K Blaser… - TRENDS in …, 2001 - cell.com
A Trautmann, M Akdis, EB Bröcker, K Blaser, CA Akdis
TRENDS in Immunology, 2001cell.com
Recently, studies on eczematous skin diseases, such as atopic dermatitis and allergic
contact dermatitis, have concentrated on T-cell-mediated immune effector mechanisms. The
apoptosis of keratinocytes induced by T cells and mediated by Fas is a crucial event in the
transition from activation of the immune system to the manifestation of eczematous
dermatitis. Here, we discuss the underlying mechanisms and molecular principles of the T-
cell-induced formation of eczema and the focused targeting of these mechanisms by …
Abstract
Recently, studies on eczematous skin diseases, such as atopic dermatitis and allergic contact dermatitis, have concentrated on T-cell-mediated immune effector mechanisms. The apoptosis of keratinocytes induced by T cells and mediated by Fas is a crucial event in the transition from activation of the immune system to the manifestation of eczematous dermatitis. Here, we discuss the underlying mechanisms and molecular principles of the T-cell-induced formation of eczema and the focused targeting of these mechanisms by potential therapies.
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