Oxidized lipids and inflammatory cytokines are believed to play a causal role in
atherosclerosis through the regulation of gene expression in macrophages and other cells.
Previous work has implicated the nuclear receptors peroxisome proliferator-activated
receptor and liver X receptor in the control of lipid-dependent gene expression and
inflammation. Here we demonstrate that expression of a third group of nuclear receptors, the
NR4A ligand-independent orphan receptors, is highly inducible in macrophages by diverse …