[HTML][HTML] Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and activator protein 1 (AP1) in metastatic squamous cell carcinoma of head and neck …
YK Mburu, AM Egloff, WH Walker, L Wang… - Journal of Biological …, 2012 - ASBMB
The chemokine receptor CCR7 is a seven-transmembrane domain G-protein-coupled
receptor that facilitates leukocyte migration to regional lymph nodes. Aberrant CCR7
expression in a number of human malignancies has been linked to pro-survival,-invasive,
and-metastatic pathways. We demonstrate here that up-regulation of CCR7 in squamous
cell carcinoma of the head and neck (SCCHN) patient tumors correlates with lower survival
because of metastatic disease. Because of this important oncogenic phenotype, we …
receptor that facilitates leukocyte migration to regional lymph nodes. Aberrant CCR7
expression in a number of human malignancies has been linked to pro-survival,-invasive,
and-metastatic pathways. We demonstrate here that up-regulation of CCR7 in squamous
cell carcinoma of the head and neck (SCCHN) patient tumors correlates with lower survival
because of metastatic disease. Because of this important oncogenic phenotype, we …