Murine mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: association with tumor-derived growth factors
KW Hunter Jr - Experimental and molecular pathology, 2007 - Elsevier
A leukemoid reaction with granulocytosis and splenomegaly has been observed in animals
and humans with a variety of tumors. We have employed four color flow cytometry to
characterize the leukemoid reaction induced by the transplantable mouse mammary
carcinoma 4T1 in female BALB/c mice. Gr-1+ myeloid cells with the morphology of
granulocytes increased in peripheral blood from< 15% pre-transplant to nearly 80% of total
CD45+ leukocytes at four weeks post-transplant. Though the granulocyte: lymphocyte ratio …
and humans with a variety of tumors. We have employed four color flow cytometry to
characterize the leukemoid reaction induced by the transplantable mouse mammary
carcinoma 4T1 in female BALB/c mice. Gr-1+ myeloid cells with the morphology of
granulocytes increased in peripheral blood from< 15% pre-transplant to nearly 80% of total
CD45+ leukocytes at four weeks post-transplant. Though the granulocyte: lymphocyte ratio …