The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling

I Fleming - Vascular pharmacology, 2016 - Elsevier
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate
epoxyeicosatrienoic acids (EETs). The latter are biologically active and reported to act as an
endothelium-derived hyperpolarizing factor (EDHF) as well as to affect angiogenic and
inflammatory signaling pathways. In addition to arachidonic acid, the CYP epoxygenases
also metabolize the Ω-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid and
docosahexaenoic acid, to generate bioactive lipid epoxide mediators. The latter can be …